在假冒的氧化片中含有etonitazepyne-一个致命的病例报告
Lena J Skarshaug1, Live Midttun1, Hege-Merete Krabseth1
1Dept. of Clinical Pharmacology, St Olav University Hospital, Trondheim, Teknostallen Professor Brochs gate 14, Trondheim, 7030, Norway.
Journal of analytical toxicology
|July 22, 2025
概括
用新型合成阿片类药物etonitazepyne致命中毒,突出了在假冒药物中识别这些危险药物的挑战. 由于尼塔所带来的健康风险很大,早期检测至关重要.
科学领域:
- 法医毒理学 法医毒理学
- 药理学 药理学是指药理学的学科.
- 滥用药物 滥用药物 滥用药物 滥用药物
背景情况:
- 西米达类阿片类药物,称为尼塔,是新兴的合成阿片类药物,娱乐用途越来越多.
- 药理和毒理学数据有限,这使得识别和管理尼塔滥用变得更加复杂.
- 含有尼塔的假冒药物构成重大风险,经常被误认为是合法的药品.
研究的目的:
- 报告一个致命的中毒病例涉及etonitazepyne,一个尼塔化合物.
- 详细说明用于在生物样本和扣押药片中识别和量化etonitazepyne的分析方法.
- 为了强调检测尼塔的挑战和假冒药物的公共卫生威胁.
主要方法:
- 开发和应用一种液体染色学-并联质谱法 (LC-MSMS) 方法.
- 在解剖过程中获得的生物样本 (股骨血液,玻璃体液) 的分析.
- 对被扣押的疑似含有etonitazepyne的药片进行毒理查.
主要成果:
- 在尸检样本中确定和量化了etonitazepyne,腿部血液度为0.32 ng/mL.
- 分析方法成功证实了假冒药片中的etonitazepyne被误认为是氧化.
- 检测到的血液度处于之前报告的致命etonitazepyne病例的较低范围.
结论:
- 这一案例凸显了对于强大的分析方法来检测新兴合成阿片类药物 (如尼塔) 的关键需求.
- 假冒的药物含有强效物质,如etonitazepyne,具有严重的,经常被低估的健康风险.
- 由于缺乏信息和获得样本的原因,ETONITAZEPYNE的识别延迟了,这突显了法医调查的挑战.
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