功能化纳夫托[2,1-d]oxazoles的合成的迪亚佐策略
Timur O Zanakhov1, Ekaterina E Galenko1, Mikhail S Novikov1
1Saint Petersburg State University, Institute of Chemistry, 7/9 Universitetskaya Naberezhnaya, St. Petersburg 199034, Russia.
The Journal of organic chemistry
|July 22, 2025
概括
通过阿齐林扩张的新氧化合成可以获得纳夫托[2,1-d]氧化. 这些化合物允许易于修饰并进一步转化为新型的[7,8]异[5,6-d]氧-7-one衍生物.
科学领域:
- 有机合成 有机合成
- 异环化学 异环化学
- 催化剂是一种催化剂.
背景情况:
- 阿齐林化学为构建复杂的异环系统提供了独特的途径.
- Rh (II) 催化反应是C-H功能化和碳素插入的强大工具.
- 纳夫托[2,1-d]奥克萨支架对药物化学和材料科学有兴趣.
研究的目的:
- 开发一种新型的合成途径,以 (oxazol-4-yl) 替代2-diazo-1,3-dicarbonyl化合物.
- 探索这些二氧化化合物的Rh (II) 催化转化到纳夫托[2,1-d]oxazole.
- 为了研究纳夫托[2,1-d]oxazole核心的后续功能化和进一步衍生.
主要方法:
- 使用三酸乙 (TFAA) 的阿齐林环扩张.
- ((II) 催化的金属碳化合物的分子内C-H插入.
- 基基团的化,然后是催化交叉合反应.
- 索诺加希拉合产品的易斯酸促进循环.
主要成果:
- 有效合成基二-子三-氧-5-/二-三甲基) 醇四-) 酸盐.
- 通过Rh (II) 催化,选择性形成4-氧纳[2,1-d]oxazole-5-carboxylic .
- 通过三和交叉合,轻松修改4位置换剂.
- 获得新型的7H-[7,8]异烯[5,6-d]氧-7-衍生物.
结论:
- 已经建立了一个用于构建功能化纳夫托[2,1-d]oxazoles的多功能合成策略.
- 开发的方法允许纳夫托[2,1-d]奥克萨核心的晚期多样化.
- 新的异环骨的合成扩大了药物发现和材料开发的化学空间.
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