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Updated: Sep 14, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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PTH通过Src-依赖的YAP稳定来抵消Hippo信号,以增强骨髓 stromal 细胞分化

Sara Monaci1, Mengrui Wu1, Hiroyuki Okada1

  • 1Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.

JCI insight
|July 22, 2025
PubMed
概括

甲状腺激素 (PTH) 信号稳定YAP蛋白质,通过通过PLC和Src激酶对抗Hippo通路. 这促进了骨髓 stromal 细胞的分化,影响骨重塑.

关键词:
骨生物学 骨生物学内分泌学 在内分泌学.骨质细胞/骨质细胞生物学

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