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开发一种LC-MS/MS方法,用于对家禽和畜牧产品中的levamisole进行分析

Ya-Chun Chou¹, Pei-Jie Zheng¹, Chih-Neng Huang¹

¹Division of Research and Analysis, Taiwan Food and Drug Administration, Ministry of Health and Welfare, No.161-2, Kunyang St, Nangang District, Taipei City, 11561 Taiwan, R.O.C.

Journal of AOAC International

|July 22, 2025

概括

一种新的合液体色谱-并联质谱法 (LC-MS/MS) 方法可以准确地检测食品中的levamisole残留物. 这种方法适用于监管监测和大规模监测牲畜和家禽中levamisole.

科学领域:

分析化学分析化学
食品安全科学食品安全科学

背景情况:

莱瓦米索尔是一种用于牲畜和家禽的甲虫剂.
监管机构已在各种食品中为牛醇设定了最大残留量 (MRL).

研究的目的:

开发一种手术性LC-MS/MS方法来确定levamisole残留物.
确保监管合规,并支持食品监督.

主要方法:

使用Astec Cyclobond I 2000 DMP柱进行状分离.
简单的溶剂提取和清洁程序.
使用液体染色学-并联质谱法 (LC-MS/MS) 进行量化.

主要成果:

该方法表现出良好的线性和0.005μg/g的低量化极限 (LOQ).
评估了不同的校准策略,使用矩阵匹配和溶剂校准曲线,为例行监测提供实用性.
在分析的商业牲畜和家禽产品中没有检测到levamisole残留物.

结论:

成功开发了一种简单,快速且经过验证的LC-MS/MS方法来定胆测定莱瓦米索尔.
该方法表现出令人满意的灵敏度,准确性和选择性,用于例行监测和监控.
开发的方法适用于确保来自牲畜和家禽的食品安全.

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