在ARIC研究中,关节间SBP差异变化与心血管事件和死亡率之间的纵向关联
Daniela Charry1, Jing Xu2, Michelle L Meyer3
1Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, USA.
American journal of hypertension
|July 22, 2025
概括
关节间缩血压差异的变化,特别是不断增加或持续大的变化,与心力衰竭和中风的风险更高有关. 监测这些血压变化可以帮助识别心血管风险增加的个体.
科学领域:
- 心血管医学 心血管医学
- 血管健康 血管健康
- 流行病学 流行病学
背景情况:
- 较大的关节间缩血压 (IASBP) 差异 (≥10或≥15 mmHg) 与不良心血管结果有关.
- 了解随着时间的推移IASBP差异变化的影响对于风险分层至关重要.
研究的目的:
- 评估IASBP差异变化与心血管事件和死亡率发生率之间的关联.
- 评估与日益增长或持久较大的IASBP差异相关的风险.
主要方法:
- 对社区动脉样硬化风险研究数据的纵向分析 (n=2051).
- 双边脚血压测量在两个时间点 (访问5和访问6/7).
- 参与者按IASBP差异 (≥10 mmHg和≥15 mmHg截止值) 分类;使用Cox比例危险回归.
主要成果:
- 增加IASBP差异 (≥10 mmHg) 与心力衰竭 (HR: 1.31) 和中风 (HR: 1.57) 的更高风险相关.
- 持续较大的IASBP差异 (≥10 mmHg) 与冠状动脉心脏病 (HR: 2.25) 和中风 (HR: 1.68) 的风险增加有关.
- 切线≥15mmHg显示了更强的关联;没有发现与死亡率的显著联系.
结论:
- 越来越多和持续大的IASBP差异是发生心血管事件风险增加的重要指标.
- 监测IASBP差异为识别心血管事件高风险个体提供了一个潜在的策略.
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