疫苗接种后的Streptococcus pneumoniae殖民和儿童的呼吸道症状:一个前性队列研究
Jaqueline Elisa Verardo Benedetti1, Kauana Pizzutti1, Mariana Preussler Mott1
1Departamento de Epidemiologia e Métodos Diagnósticos, Programa de Pós Graduação Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil.
细菌肺炎菌的殖民化并没有增加接种疫苗的儿童的呼吸道感染,除了2岁以下儿童的血清型6B肺炎. 这项研究追踪了接种疫苗的儿童一年.
科学领域:
- 儿童传染病 儿童传染病
- 疫苗学 疫苗学 疫苗学
- 微生物学 微生物学
背景情况:
- 在全球范围内,Streptococcus pneumoniae会导致儿童呼吸道感染.
- 肺炎球菌联合疫苗 (PCV10,PCV13) 的目的是减少疾病负担.
- 了解疫苗接种后的殖民化动态对于公共卫生至关重要.
研究的目的:
- 评估Streptococcus pneumoniae殖民对接种疫苗的儿童感染发病率的影响.
- 在一年的随访期间,评估肺炎球菌携带者和呼吸道疾病之间的关系.
主要方法:
- 225名儿童 (18-59个月) 接种PCV10或PCV13疫苗的前性队列研究.
- 一年后的随访,包括采访和医疗记录审查.
- 使用波桑回归和奇平方/费舍尔精确试验的统计分析.
主要成果:
- 观察到高殖民率 (64.4%);只有2.8%携带疫苗血型.
- 男性性别与殖民化有关 (p=0.05).
- 在被殖民的儿童中,呼吸系统疾病或抗微生物药物使用的风险没有增加,除了2岁以下儿童的血清型6B和肺炎 (p=0.016).
结论:
- 肺炎球菌携带不会显著增加完全接种疫苗的儿童的呼吸道疾病发病率.
- 血清型6B的定居与两岁以下儿童的肺炎有关.
- 这些发现有助于制定疫苗接种策略和疾病监测.
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