发展健康和疾病预防服务的协议:基于炼的预测模型,整合基因组测试结果
1School of Kinesiology, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea.
PloS one
|July 22, 2025
概括
这项研究探讨了利用基因组数据进行个性化,高强度的炼计划,以改善癌症患者的治疗结果. 埃克塞萨勒斯移动应用程序将为预防和生活质量量量身定制运动.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 运动科学 运动科学
- 数字健康数字健康
背景情况:
- 癌症是全球主要的死亡原因.
- 运动干预措施对癌症患者的身体和精神健康有很大的前景.
- 针对使用基因组数据的量身定制的高强度炼计划存在有限的证据.
研究的目的:
- 评估EXESALUS移动应用程序对个性化运动干预措施的可行性和影响.
- 将基因组分析与癌症预防,肌肉强度增强和改善生活质量的运动方案相结合.
- 评估定制高强度运动作为预防和治疗策略的潜力.
主要方法:
- 一个为期3个月的,并行组,随机对照试验,涉及500名参与者 (100名癌症患者,300名风险人群).
- 参与者将使用EXESALUS计划,以量身定制的低,中和高强度炼,辅导和可穿戴反.
- 在基线,6周和3个月收集的生物样本,以分析基因组变异和生理变化.
主要成果:
- 主要结局:体力表现 (SPPB),肌肉力量 (1RM,峰值功率) 和骨肌肉质量 (DXA).
- 二次结果:疲劳 (FACIT-F),恢复力,焦虑,抑郁和生活质量.
- 基因组变异和生理变化将在整个试验中进行评估.
结论:
- 这项研究为基于ICT的个性化炼干预提供了一个框架,其中包括基因组分析.
- 预计EXESALUS计划将证明针对癌症患者和风险人群量身定制的高强度运动的价值.
- 这些发现将有助于精准医学,用于使用可扩展的ICT解决方案预防和管理癌症.
更多相关视频
11:35Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
Published on: August 21, 2016
13.1K
07:15Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
11.1K
相关概念视频
Genome-wide Association Studies-GWAS
14.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.3K
Models of Health Promotion and Illness Prevention I
2.2K
A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
2.2K
Models of Health Promotion and Illness Prevention II
1.7K
The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results...
The agent-host-environment model states that disease results...
1.7K
Human Genetics
730
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
730
