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Updated: Sep 14, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Published on: July 17, 2019

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基于报告器的查识别了RAS-RAF突变作为在结直肠癌中对活性状态RAS抑制剂耐药性的驱动因素

Oleksandra Aust1, Moritz R T Thiel1, Eric Blanc2

  • 1Institute of Pathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Science signaling
|July 22, 2025
PubMed
概括

广谱RAS抑制剂对KRAS突变结直肠癌 (CRC) 起初有效,但通过KRAS或RAF1突变出现耐药性. 针对RAS和RAF的组合疗法可以克服这种获得的耐药性.

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