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Updated: Sep 14, 2025

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(反向) 一个淫荡的异合体Pyruvate Lyase的演变成为一个高效的合体Mutase

Dominik E Künzler1, Luca Bressan1, Linda Jäger1

  • 1Laboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland.

Biochemistry
|July 22, 2025
PubMed
概括

定向进化将一种异合酸盐酸酶 (IPL) 转化为一种高效的合酸盐突变酶 (CM). 这项研究揭示了对酶进化和活性部位可塑性的洞察力,用于环周反应.

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