经期四年的更年期激素治疗对白质完整性的长期影响
Laura L Faubion1, Elijah Mak1, Firat Kara1
1Department of Radiology.
概括
经过四年的更年期激素治疗 (mHT) 没有对最近更年期妇女的脑白质完整性产生长期影响. 这项研究支持短期使用mHT对大脑健康的安全性.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 更年期激素治疗 (mHT) 用于管理更年期症状.
- 人们担心mHT对大脑健康的长期影响,特别是白质结构.
- 在更年期左右早期启动mHT可能会影响结果.
研究的目的:
- 评估4年绝经期激素治疗 (mHT) 对大脑白质完整性的长期影响.
- 评估在更年期开始后3年内启动mHT是否会在十年后影响白质架构.
主要方法:
- 利用了克罗诺斯早期雌激素预防研究 (KEEPS) 和其观察后续的数据,KEEPS继续.
- 使用白质超强度体积,扩散磁共振成像 (dMRI) 和干预后10年的脑梗塞来评估白质完整性.
- 采用线性回归模型来比较mHT治疗臂 (口服结合性马雌激素,透皮17β-雌激醇) 和安慰剂之间的白质指标.
主要成果:
- 在dMRI指标中,在mHT组 (口服结合马类雌激素,透皮17β-雌激醇) 和安慰剂之间没有观察到显著差异.
- 与安慰剂相比,白质超强度体积和脑梗塞发生率在治疗手臂中没有显著差异.
- 分析包括266名参与者 (平均年龄67岁),其中94人在安慰剂组.
结论:
- 在更年期早期开始的四年更年期激素治疗似乎对白质完整性没有长期不良影响.
- 这些发现与新出现的证据一致,这些证据表明短期使用mHT对最近绝经后妇女的安全性.
- 进一步的研究可能会探索早期mHT对认知功能和大脑健康的持续影响.
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