在焦点发作中持续的正面性中枢性呼吸暂停:发生率,特征和成像发现
Stefano Meletti1,2, Margherita Burani1,2, Alice Ballerini1
1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.
Neurology
|July 22, 2025
概括
静脉中心呼吸暂停 (PICA) 发生在约6%的焦点中,并且与更长的呼吸暂停持续时间有关. 在患有PICA的患者中观察到桃体体积增加,这表明发作和呼吸障碍之间存在联系.
科学领域:
- 神经学 神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 心血管呼吸系统生理学
背景情况:
- 后性中央呼吸暂停 (PICA) 越来越被认为是中突然无法解释死亡的一个因素.
- 了解焦点发作中PICA的发病率和特征对于患者的安全至关重要.
研究的目的:
- 确定PICA在焦点发作发作的发病率和特征.
- 为了研究PICA患者的杏仁体和其他皮层下自主控制结构的形态差异.
主要方法:
- 使用心肺呼吸学测谎仪进行长期视频EEG监测 (LTVEM) 的患者的未来招募.
- 在焦点发作期间评估ictal中心呼吸暂停 (ICA) 和PICA的存在和特征.
- 对杏仁体,海马体,丘脑,大脑干和小脑进行体积测量分析,比较患有和没有周周呼吸障碍的患者.
主要成果:
- 在12名患者中,PICA在5.9%的焦点发作中被观察到,主要是患有叶的人.
- 与PICA的发作患者相比,PICA的发作患者表现出明显更长的周周无呼吸时间和延迟的呼吸恢复后的发作,与自我限制的外周无呼吸患者相比.
- 患有ICA/PICA的患者与对照组和没有发作性呼吸暂停的患者相比,显示出桃体体积扩大,与发作区域相对侧向.
结论:
- 在约6%的焦点发作中存在PICA,并与长时间的呼吸暂停和扩大的ipsilateral杏仁体有关.
- 研究结果表明,门呼吸暂停和后门呼吸暂停之间存在连续性,这强调了在LTVEM期间心肺呼吸系统监测的重要性.
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