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内分泌干扰化学物质对保持比率受损螺旋计的潜在影响,由五种不同的方法揭示出来
Chenyuan Deng1, Yu Jiang1, Yuechun Lin1
1Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
暴露于内分泌干扰化学物质 (EDC) 与保留比率受损螺旋计 (PRISm) 相关,这是COPD的前体. 单异布甲酸 (MIBP) 是一个关键的贡献者,尿酸和SII充当中介.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 干扰内分泌的化学物质 (EDC),包括和酸盐,被认为是慢性阻塞性肺病 (COPD) 的环境风险因素.
- 保持比率受损螺旋计 (PRISm) 是COPD的公认前体.
- 之前没有研究过EDC暴露与PRISm之间的关联.
研究的目的:
- 检查暴露于EDC和PRISM之间的关系.
- 确定特定的EDC为PRISm做出贡献.
- 探索潜在的调解途径,并为PRISm开发一个预测模型.
主要方法:
- 分析了NHANES 2007-2012数据集中的1363名参与者的数据.
- 对于个别的EDC协会使用多重后勤回归,以及用于组合EDC效应的三个混合模型 (WQS,Qgcomp,BKMR).
- 研究尿酸和SII的调解,并使用人口和EDC数据开发了PRISM的识别模型.
主要成果:
- 在EDC混合物和PRISm之间发现了显著的积极关联,每单位增加EDC混合物指数时,PRISm的几率增加 (WQS:OR=1.63;Qgcomp:OR=1.41).
- 单异布甲酸盐 (MIBP) 成为与PRISM相关的最重要的个人EDC (OR=2.29).
- 尿酸和SII部分调解了混合EDC和PRISM之间的关联 (分别为15.6%和15.8%).
结论:
- 暴露于EDC与PRISM的患病率有关.
- 这项研究为EDCs在PRISm发展中的作用提供了新的流行病学证据.
- 调查结果强调MIBP是PRISm的关键环境预测因素.
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