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通过对现实世界的数据进行自我控制的病例系列分析,验证社区对与COVID-19疫苗接种相关的月经变化的担忧

Aishwarya N Shetty¹, Gonzalo Sepulveda Kattan¹, Muhammad Javed¹

¹Epidemiology Informatics, Centre for Health Analytics, Melbourne Children's Campus, Melbourne, Australia; SAEFVIC, Murdoch Childrens Research Institute, Melbourne, Australia.

|July 22, 2025

概括

接种COVID-19疫苗,特别是mRNA疫苗,与月经干扰报告的暂时增加有关. 这项研究证实了人们对疫苗接种后月经变化的担忧,为公众提供了保证.

科学领域:

免疫学免疫学免疫学
公共卫生公共卫生
现实世界的证据.

背景情况:

在COVID-19疫苗接种后,有关月经变化的事报告非常普遍.
对疫苗副作用的担忧可能会加剧犹,需要基于证据的验证.

研究的目的:

为了调查COVID-19疫苗接种和月经干扰之间的潜在联系.
为了解决和验证社区对疫苗接种后月经健康的担忧.

主要方法:

利用一个深度学习框架 (VaxPulse) 来分析社交媒体关于月经变化和COVID-19疫苗接种的讨论.
对15-49岁女性的澳大利亚一般实践数据 (2021-2023) 进行了自我控制的病例系列 (SCCS) 分析,按疫苗平台分层.
评估月经干扰的相对发病率 (RI) 在接种疫苗后六周内诊断出月经干扰,并监测回归基线.

主要成果:

识别了70,977个社交媒体帖子,讨论疫苗接种后的月经不规则.
mRNA COVID-19 疫苗接种显示,月经干扰呈现的情况在统计学上显著增加 (RI:1.14,95% CI:1.07-1.22).
这种增加是暂时的,在7周内明显,但在接种疫苗后13周消散.

结论:

在mRNA COVID-19疫苗接种后,月经变化呈现的临时增加得到证实.
这些发现证实了社交媒体上提出的担忧,支持接种疫苗的人和考虑接种疫苗的人.
强调了大型现实世界数据集的实用性,以告知公共卫生决策.

关键词:

关于COVID-19疫苗的使用情况经期的干扰经期的干扰现实世界的数据数据.社交媒体社交媒体监督监督监督监督监督监督疫苗的安全性疫苗的安全性

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