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Updated: Sep 14, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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创新的双 AKT 抑制剂揭示了新的机制和翻译潜力

Shuang Yan1, Lin Wang2, Dan Liu3

  • 1Sichuan University of Arts and Science, DaZhou 635000, China; Key Laboratory of Exploitation and Study of Distinctive Plants in Education Department of Sichuan Province, DaZhou 635000, China; Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, ZiGong 643002, China; Key Laboratory of Low-cost Rural Environmental Treatment Technology at Sichuan University of Arts and Science, Education Department of Sichuan Province, DaZhou 635000, China.

Bioorganic chemistry
|July 22, 2025
PubMed
概括

双标AKT抑制剂通过同时向多种途径,克服耐药性并提高效率,提供了增强的癌症治疗,与传统单标药物相比. 未来的研究重点是新的策略,如纳米输送和组合疗法.

关键词:
在AKT信号传输中.临床 临床 临床 临床双目标抑制剂的双目标抑制剂纳米药物输送系统提供系统.在PI3K/AKT/mTOR信号通路中.

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