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响应超声波的压电止痛微球缓解骨关节炎疼痛

Xinhe Li¹, Fan Wang², Xinyu Zhang¹

¹Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

Journal of controlled release : official journal of the Controlled Release Society

|July 22, 2025

概括

新的超声响应微球有效地通过产生电脉冲来阻止疼痛信号来治疗骨关节炎疼痛. 这种创新疗法在治疗慢性疼痛和关节损伤方面表现有前途.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
疼痛管理疼痛管理

背景情况:

骨关节炎 (OA) 是慢性疼痛的主要原因,有效治疗方法有限.
目前的OA疼痛疗法往往为患者提供不满意的结果.
需要新的方法来有效地缓解OA疼痛和管理关节损伤.

研究的目的:

开发超声响应的压电止痛微球来缓解OA的疼痛.
通过发电脉冲和通道调节来研究缓解疼痛的机制.
为了评估这些微球在体外和体外的疗效.

主要方法:

使用微流体制造复合水凝微球 (GelMA/HAMA).
用狂犬病病毒糖蛋白 (RVG) 修改的压电纳米颗粒加载酸 (BaTiO3).
在体外评估与疼痛相关的分子表达和在OA大鼠模型中的体内研究.

主要成果:

成功建造了BaTiO3-RVG@GA/HA镇痛微球.
超声波刺激产生了电脉冲,阻断了Nav1.7电压通道.
实验室研究显示疼痛分子表达减少;体内研究表明,老鼠疼痛行为和关节损伤减少.

结论:

响应超声波的压电微球为OA疼痛管理提供了一个有希望的新策略.
开发出来的微球有效地缓解了OA的疼痛,并减少了关节病理.
这项技术在改善OA疼痛和关节损伤治疗方面具有显著的潜力.

关键词:

疼痛缓解微球是一种微球.Na(v) 1.7 在这个问题上.骨关节炎疼痛骨关节炎的疼痛压电纳米材料是什么超声波超声波是指超声波的使用.

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