重复的远程缺血预调可以改善皮肤微血管反应对闭塞后反应性高血压的时间特征
Jahyun Kim1,2, Warren D Franke2, James A Lang2
1Department of Kinesiology, California State University Bakersfield, Bakersfield, California, United States.
概括
重复的远程缺血预调 (RIPC) 增强了微血管反应能力,但只有更长的持续时间会改变时间反应. 这项研究表明,RIPC改善了闭塞后反应性高血压 (PORH) 的测量,这表明对血液循环的潜在益处.
科学领域:
- 生理学 生理学 生理学
- 心血管科学 心血管科学
- 微循环是一种微循环.
背景情况:
- 已知反复远程缺血预调 (RIPC) 可以改善内皮功能和皮肤血管扩张.
- 重复的RIPC对皮肤微血管中的封闭后反应性高血压 (PORH) 的影响仍然在很大程度上未被探索.
研究的目的:
- 调查重复的RIPC是否增强皮肤微血管中的PORH反应.
- 为了确定更长时间的RIPC是否能进一步改善微血管反应能力.
主要方法:
- 30名参与者接受了1周 (n=10) 或2周 (n=12) 的RIPC,或作为2周的对照 (n=8).
- 每次RIPC会话都包括4个5分钟的臂塞周期,然后是5分钟的再注血.
- 在5分钟臂动脉封闭后,使用激光光斑对比成像测量PORH,评估皮肤血管导电性 (CVC).
主要成果:
- 1周和2周的RIPC同样改善了最大高血压与达到峰值的时间 (Max/Tp) (P <0.05) 的比率.
- 只有在RIPC的2周后,PORH的高峰时间 (Tp) 显著减少 (P <0.05).
- 在RIPC前后的测量和在不同组之间,PORH的大小 (曲线下面的面积和峰值) 没有差异.
结论:
- 重复的RIPC改善了封闭后皮肤微血管反应的时间方面,特别是反的速度.
- 虽然1周的RIPC显示了一些好处,但需要2周才能改变时间PORH变量,如Tp.
- 这些发现表明,重复的RIPC增强了微血管反应能力,更长的持续时间可能会产生更明显的时间适应.
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