可穿戴双网等离子水凝用于SERS检测汗液中的尿素和尿酸
Jing Zhu1, Wenrou Yu1, Hongyuan Xiong1
1Chongqing Key Laboratory of Interface Physics in Energy Conversion, College of Physics, Chongqing University, Chongqing 401331, China.
ACS sensors
|July 22, 2025
概括
带有银纳米颗粒的新型可穿戴水凝传感器可以在汗水中超敏感检测尿素和尿酸. 这种灵活的设备显示了通过非侵入性生物标志物监测的早期疾病诊断的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 分析化学 分析化学
背景情况:
- 传统的汗水检测设备缺乏灵敏度和机械灵活性.
- 水凝和表面增强拉曼光谱 (SERS) 提供了改进可穿戴传感器的潜力.
研究的目的:
- 开发一种机械灵活,快速和超灵敏的可穿戴等离子双网络 (PDN) 水凝传感器.
- 使用SERS在合成汗液中检测尿素和尿酸.
主要方法:
- 在现场制造PDN水凝,其中包含银纳米粒子 (AgNPs).
- 使用聚乙烯醇 (PVA) 来增强水凝弹性.
- 使用SERS和机器学习模型分析生物标志物.
主要成果:
- 在汗水中,PDN水凝对检测尿素 (10 pM) 和尿酸 (1 nM) 具有很高的灵敏度.
- 水凝表现出极好的机械性能,允许重复拉伸.
- 均的AgNP分散增强了SERS检测灵敏度和稳定性.
结论:
- 开发的PDN水凝传感器因其灵活性和灵敏度而适合于可穿戴应用.
- 这项技术具有通过汗水生物标志物分析进行非侵入性疾病诊断的巨大潜力.
- 机器学习分析证实了尿素和尿酸在汗水生物标记物识别中的作用.
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