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在雄性动物袖子胃切除术后,肠道微生物组和胆酸的变化:什么是第一位的?

Elizabeth C Welsch¹, Matthew R Barron², Katelyn M Storage²

¹Medical College of Wisconsin College of Medicine, Milwaukee, Wisconsin, United States.

American journal of physiology. Regulatory, integrative and comparative physiology

|July 22, 2025

概括

袖子胃切除术通过改变肠道微生物群和增加胆酸池来改善新陈代谢. 这种手术减少体重增加,改变肝脏基因表达,影响胆酸循环和微生物组成.

科学领域:

代谢手术代谢手术
肠道微生物组研究研究
胆酸新陈代谢胆酸新陈代谢

背景情况:

袖子胃切除术 (SG) 改善了代谢健康,但涉及肝脏,胆酸 (BA) 池和肠道微生物组的机制是复杂的.
在SG后这些因素之间的相互作用尚未完全理解,这阻碍了有针对性的治疗开发.

研究的目的:

调查SG是否会改变肠道微生物群,从而增加BA池和代谢效益.
阐明 SG 诱导的特定微生物和代谢变化及其因果关系.

主要方法:

从SG或假操作小鼠转移便物质 (FMT) 到未经手术操作的小鼠.
对BA度,与BA相关的肝酶和肠道微生物组合 (16S和元基因组分析) 的分析.
对体重增加和肝脏基因转录的评估 (slc10a1,cyp8b1).

主要成果:

与假手术相比,SG显著减少了体重增加.
SG增加了BA池,并降低了slc10a1和cyp8b1.1的肝脏转录.
SG便的FMT降低了接受者小鼠的BA池,而SG手术增加了BA池和改变了微生物组成,包括增加*Ligilactobacillus*产生的胆盐酸酶的物种.

结论:

SG的代谢益处与肝脏转录cyp8b1和slc10a1的降低,增加BA池和改变BA循环有关.
肠道微生物群适应这些变化,增加*Ligilactobacillus*和胆盐酸酶的产生,可能有助于后SG代谢改善.
FMT研究表明,微生物组在调解SG对BA新陈代谢的影响方面起着作用.

关键词:

减肥手术减肥手术是什么胆酸胆酸是一种胆酸.在cyp8b1中使用我们的肠道微生物组.石墨烯酸是指石墨烯酸中的一种.

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