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Updated: Sep 14, 2025

Direct Detection of the Acetate-forming Activity of the Enzyme Acetate Kinase
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Published on: December 19, 2011

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机械洞察力 关于来自Mycobacterium tuberculosis的同类素O-乙转移酶的机械洞察力

Wanting Jiao1,2, Gerd Mittelstädt1,2, Alistair T Richardson1,2

  • 1Ferrier Research Institute, Victoria University of Wellington, Wellington 6140, New Zealand.

Biochemistry
|July 22, 2025
PubMed
概括

研究了对病原体中 metionin 生物合成至关重要的 MetX 酶. 它的催化三位一体.

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ATP Synthase: Structure

ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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