在COVID-19大流行期间加速大脑衰老
Ali-Reza Mohammadi-Nejad1,2,3, Martin Craig2, Eleanor F Cox1,4
1National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Queen's Medical Centre, Nottingham, United Kingdom.
Nature communications
|July 22, 2025
概括
在健康个体中,COVID-19大流行加速了大脑衰老平均5.5个月,独立于SARS-CoV-2感染. 这种效应在男性和来自贫困背景的人群中更为明显,影响大脑健康,而不仅仅是直接感染.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- SARS-CoV-2和COVID-19大流行病对大脑健康的影响是公认的,但研究不足.
- 大脑衰老是认知能力下降和整体健康的关键因素.
研究的目的:
- 通过使用纵向神经成像数据,调查大流行对大脑衰老的影响.
- 为了确定疫情是否加速大脑衰老,独立于SARS-CoV-2感染.
主要方法:
- 训练有素的大脑年龄预测模型在15334名健康参与者的多式成像特征上 (英国生物银行).
- 将模型应用于996名健康参与者的独立队列,并进行大流行前和后的MRI扫描.
- 对照组和流行组之间的脑年龄差异变化进行了比较,分析了人口统计和感染状况.
主要成果:
- 与对照组相比,流行病组显示大脑衰老显著加速 (大脑年龄差距平均增加5.5个月).
- 加速的大脑衰老在男性和来自贫困社会人口背景的个人中更为明显.
- 无论SARS-CoV-2感染,都发生了加速的大脑衰老,但仅在感染的参与者中与认知能力下降相关.
结论:
- 随着COVID-19的流行,大脑衰老显著加快,这与直接的SARS-CoV-2感染无关.
- 与大流行相关的更广泛的社会和健康因素有助于加速大脑衰老.
- 研究结果强调,需要解决社会和健康不平等问题,以了解大流行病对健康的长期影响.
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