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Updated: Sep 14, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Published on: May 3, 2018

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通过CDK1对USP33的酸化稳定了mTORC2组件SIN1的稳定性

Yalei Wen1,2, Caishi Zhang3, Mingchao Liang4

  • 1Research Institute for Maternal and Child Health, The Affiliated Guangdong Second Provincial General Hospital, Postdoctoral Research Station of Traditional Chinese Medicine, School of Pharmacy, Jinan University, Guangzhou, China.

Cell death & disease
|July 22, 2025
PubMed
概括

增加的SIN1表达通过稳定mTORC2.2驱动胰腺癌化学抵抗. 向CDK1-USP33轴会破坏SIN1的稳定,提高化疗敏感性,改善胰腺管道腺癌患者的生存结果.

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