高清透直流刺激治疗慢性失眠的效果:一项随机,双盲,受控试验
Jialu Li1, Aonan Li2, Jiajia Jiao1
1Department of Neurology, First Affiliated Hospital of Anhui Medical University, Anhui Medical University, 218 Jixi Road, Hefei, 230022, People's Republic of China.
Scientific reports
|July 22, 2025
概括
在慢性失眠患者中,通过背部中部前额叶皮层进行高清度横直流刺激 (HD-tDCS) 改善了睡眠质量,减少了白天的嗜睡. 这种非侵入性神经调节显示出作为补充疗法的前景.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
背景情况:
- 慢性失眠严重影响生活质量.
- 目前的治疗方法包括药物治疗和认知行为疗法,但需要新的方法.
研究的目的:
- 在慢性失眠患者中,评估针对背部中部前额皮层 (DMPFC) 的10天高清度横直流刺激 (HD-tDCS) 的疗效.
主要方法:
- 55名患有慢性失眠的患者被随机分配到活跃的HD-tDCS或假刺激组.
- HD-tDCS涉及对DMPFC (Fz) 的阳极刺激和在FPz,F3,Cz,F4.4的阴极放置.
- 睡眠评估包括治疗前后的多睡眠图 (PSG) 和自我报告的尺度 (例如,PSQI).
主要成果:
- 活跃的HD-tDCS组与虚假组相比,匹兹堡睡眠质量指数 (PSQI) 得分显著降低.
- 探索性分析表明,通过PSG,睡眠开始延迟 (SOL) 和睡眠效率 (SE) 得到改善.
- 没有观察到对睡眠阶段比率的显著影响.
结论:
- 适用于DMPFC的HD-tDCS有效促进睡眠和改善慢性失眠中的每日嗜睡.
- HD-tDCS代表了慢性失眠的潜在辅助疗法,需要进一步研究复制和安全数据.
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