年轻人的表观遗传年龄和大脑年龄之间的关联
Faye Sanders1, Vilte Baltramonaityte1, Gary Donohoe2,3
1Department of Psychology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Scientific reports
|July 22, 2025
概括
生物年龄测量,包括表观遗传和大脑年龄,在年轻人中显示出变化. 这些指标彼此之间没有很强的相关性,也没有与青春期的健康和认知特征有很强的相关性.
科学领域:
- 发展生物学 发展生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 神经科学是一个神经科学.
背景情况:
- 通过表观遗传或神经成像评估的生物年龄可以比时间年龄更好地预测成人健康.
- 关于这些生物年龄指标在年轻人群中的适用性和相互作用的研究有限.
研究的目的:
- 描述年轻个体多种生物年龄测量的表现和相互依赖.
- 检查青春期生物年龄测量和各种健康指标之间的关系.
主要方法:
- 使用来自ALSPAC队列的纵向子样本 (n=386).
- 来自血液样本 (17-19岁) 的四个表观遗传年龄测量和神经成像 (18-24岁) 的一个大脑年龄测量.
- 评估生物年龄指标与身体,认知和心理健康指标 (8-18岁) 之间的关联.
主要成果:
- 发现大脑年龄和表观遗传年龄之间很少存在关联 (p > 0.05).
- 吸烟 (DNAm) 与先进的表观遗传年龄 (PACE和张钟) 相相关,BMI (sds) 与先进的EpiAge (Horvath差异) 相相关,但与大脑年龄无关.
- 抑郁症状和认知能力与所有生物年龄指标无关.
结论:
- 表观遗传和大脑年龄的测量在年轻人中表现出显著的变化.
- 目前的生物年龄指标可能无法完全捕捉青少年的发育轨迹或健康状况.
- 需要进一步的研究来追踪年轻人群的衰老过程.
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