糖尿病患者的系统性炎症和CCD和恶性瘤死亡率的综合指数之间的关系
Zhihui Li1, Hua Li1, Peng Wang1
1The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Scientific reports
|July 22, 2025
概括
糖尿病患者全身炎症总指数 (AISI) 升高显著增加了心脑血管疾病和恶性瘤的死亡风险. 较高的AISI表明糖尿病患者的生存结果较差.
科学领域:
- 生物标志物和疾病结果.
- 炎症和慢性疾病的疾病.
背景情况:
- 系统性炎症是糖尿病病理生理学的组成部分.
- 系统性炎症综合指数 (AISI) 是一种用于炎症评估的新生物标志物.
- 关于AISI与糖尿病人群死亡率相关的数据有限.
研究的目的:
- 调查AISI与死亡风险之间的关联.
- 检查不同AISI水平的糖尿病患者心脑血管疾病 (CCD) 和恶性瘤死亡率的风险.
主要方法:
- 从2001-2018年国家健康和营养检查调查 (NHANES) 的数据分析.
- 使用多变量调整的考克斯模型,卡普兰-梅尔分析和受限立方斜线 (RCS) 分析.
- 进行了子组和灵敏度分析以证实发现.
主要成果:
- 较高的AISI水平与CCD死亡率的增加密切相关 (HR 1.18,95% CI 1.11-1.26).
- 增加的AISI水平与恶性瘤死亡率的增加密切相关 (HR 1.20,95% CI 1.10-1.30).
- 较高的AISI与糖尿病患者的存活率降低相关,这两种情况.
结论:
- 在患有糖尿病的成年人中,AISI升高是增加死亡风险的重要预测因素.
- 正如AISI所指出的,较高的全身炎症与糖尿病患者心脑血管疾病和恶性瘤的较差结果有关.
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