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在口味掩饰中使用热挤出技术
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
AAPS PharmSciTech
|July 22, 2025
概括
热挤出 (HME) 是一种无溶剂的方法,通过在聚合物矩阵中嵌入活性药物成分 (API) 来掩盖苦药的味道. 这种技术提高了口感,特别是对于儿科和老年人药物配方.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 热挤出 (HME) 是一种关键技术,用于掩盖苦味的活性药物成分 (API).
- 这种无溶剂的连续过程产生了聚合物矩阵屏障,以减少苦味的感知.
- 对儿科,老年和兽医药物配方而言,可口味性至关重要.
研究的目的:
- 审查HME在口味掩饰中的应用和有效性.
- 为了突出关键参数和辅助剂选择,成功地掩盖味道.
- 讨论未来在HME中取得的进展,以提高药物的可口性.
主要方法:
- 化聚合物矩阵并将API纳入.
- 挤出过程以形成颗粒或最终剂型.
- 优化工艺参数 (温度,螺丝速度,药物与聚合物比率) 和螺丝配置.
主要成果:
- 通过在API周围形成保护性聚合物屏障,HME有效地掩盖了苦味.
- 助剂的选择和兼容性对于成功的口味掩饰至关重要.
- 工艺参数和螺丝设计显著影响口味掩饰的有效性.
结论:
- HME是一种高效和多功能技术,用于掩盖具有挑战性的味道API.
- 聚合物和工艺分析技术 (PAT) 的进一步创新将提高HME的有效性.
- HME为开发患者友好的口服药物做出了贡献.
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