在黄金地松鼠冬眠期间控制呼吸
Michael B Harris1,2, William K Milsom3
1Department of Biological Sciences, California State University Long Beach, Long Beach, CA, 90840, USA.
冬眠中的松鼠会连续呼吸. 阴道反和NMDA受体调节这种模式,阴道反对于调节呼吸发作和对CO2的反应至关重要.
科学领域:
- 生理学 生理学 生理学
- 神经科学是一个神经科学.
- 冬眠生物学 冬眠生物学
背景情况:
- 冬眠的哺乳动物表现出独特的呼吸模式,包括由呼吸暂停分开的偶发呼吸.
- 肺伸展受体和N-甲基-D-酸盐 (NMDA) 受体是这些模式的潜在调节者.
研究的目的:
- 为了研究状 afferent反和NMDA受体活性在冬眠黄金地松鼠的插曲性呼吸中的作用.
- 为了确定这些调节器对呼吸系统对缺氧和高头反应的影响.
主要方法:
- 在冬眠中的松鼠中使用MK-801破坏阴道反和阻断NMDA受体.
- 分析呼吸模式,包括每次呼吸和整体通风.
- 对低氧和高头的呼吸系统反应的评估.
主要成果:
- 冬眠中的松鼠表现出偶发的呼吸,对高头有强烈的反应,但没有缺氧.
- 阴道阻塞减少了每次呼吸,减少了通风,并取消了超内反应.
- MK-801增加了每次和频率的呼吸次数,但没有影响整体通风或气反应.
- 联合封锁取消了偶尔呼吸和诱导性兴奋.
结论:
- 阴道反和NMDA受体过程调节冬眠中的松鼠的呼吸.
- 阴道反似乎对调节呼吸发作和超性反应至关重要.
- 这些机制在启动偶发呼吸中的确切作用需要进一步研究.
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