生物疗法在炎症性肠道疾病中的利用趋势:来自沙特阿拉伯的叙事审查
Syed A Gardezi1, Turki AlAmeel2, Eman AlSulais3
1Department of Gastroenterology, Johns Hopkins HealthCare Aramco, Eastern Province, Saudi Arabia.
概括
在沙特阿拉伯,对炎症性肠病 (IBD) 的生物治疗使用正在增长,Infliximab和Adalimumab是最常见的. 新的药物和生物仿制药显示出个性化,经济高效的治疗的前景.
科学领域:
- 胃肠道学和免疫学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 沙特阿拉伯的炎症性肠病 (IBD) 患病率正在上升.
- 关于该地区的生物利用,结果和成本的数据有限.
- 需要对沙特IBD生物数据进行全面的综合.
研究的目的:
- 评估沙特阿拉伯对IBD生物利用的国家趋势.
- 综合有关生物有效性,结果和成本影响的数据.
- 确定该地区IBD管理的未来方向.
主要方法:
- 在PubMed,科克伦图书馆,谷歌学者和当地期刊进行全面的文献搜索,截至2025年4月.
- 包括关于沙特IBD患者生物使用,成本,有效性或结果的研究.
- 由于研究设计的异质性,数据的叙述综合.
主要成果:
- 七项研究分析了近1000名患者;infliximab和adalimumab是最常被处方的.
- 在性结肠炎 (UC) 和阿达利木马布治疗中观察到更高的治疗失败率.
- 乌斯特基努马布和维多利祖马布在抗TNF耐药病例中显示出有效性,包括儿科病例.
- 在99%的患者中,与健康相关的生活质量 (HRQoL) 得到改善.
- 每年的成本从5,572美元到18,424美元不等;生物类似药显示出潜在的成本节省.
结论:
- 在沙特阿拉伯,生物治疗的使用正在增加,并趋向于个性化医疗.
- 生物类似药和剂量优化为潜在的成本节约提供了机会.
- 高质量的纵向数据和国家IBD注册表对于指导临床决策和政策至关重要.
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