在美国的真菌脑膜炎. 在墨西哥马塔莫洛斯接受外周麻醉的患者
Dallas J Smith1, Elizabeth Misas1, Jeremy A W Gold1
1Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States.
概括
在墨西哥,与外周麻醉相关的罕见真菌脑膜炎疫情影响了美国患者,导致高死亡率. 鉴定出Fusarium solani物种复合体是造成这种情况的原因.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 菌类学 菌类学是指菌类学.
背景情况:
- 菌性脑膜炎的爆发很少发生,但与高死亡率有关.
- 在2023年5月,对由Fusarium solani物种复合体引起的真菌脑膜炎疫情进行了调查.
- 疫情影响了在墨西哥马塔莫罗斯接受了涉及外周麻醉的手术的美国患者.
研究的目的:
- 为了调查与墨西哥施加的外周麻醉相关的真菌脑膜炎疫情.
- 为了确定致病原体和传播途径.
- 为公众健康指导和临床反应提供信息.
主要方法:
- 从潜在暴露的美国居民收集流行病学数据.
- 临床数据审查,包括诊断腰部穿刺.
- 来自患者和诊所的Fusarium分离物的全基因组测序.
- 公共卫生官员的通知和联系人追踪.
主要成果:
- 在233名可能暴露的美国居民中,有170人得到了帮助;104人报告了外周麻醉.
- 24人被诊断患有真菌性脑膜炎,12人死亡 (50%的死亡率).
- 所有受影响的患者都接受了同一个麻醉师的麻醉; Fusarium 隔离物是遗传相关的.
结论:
- 临床医生必须怀疑真菌脑膜炎的患者有负面的细菌/病毒测试和外周麻醉史.
- 疫情突出了与医疗旅游和外围麻醉下手术相关的风险.
- 迅速识别和应对对于管理罕见但严重的传染病爆发至关重要.
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