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在加拿大队列中的婴儿酸抑制药物,C. difficile殖民化和儿童体重指数

Sarah L Bridgman¹, Kelsea M Drall¹, Amanda A Lau¹

¹Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Acta paediatrica (Oslo, Norway : 1992)

|July 23, 2025

概括

婴儿使用组胺-2受体对抗剂 (H2RAs) 与更高的学前体质指数 (BMI) 有关. 这种关联是由Clostridioides difficile (C. difficile) 殖民的介导,这表明肠道微生物群的途径.

科学领域:

儿科健康儿科健康
微生物组研究微生物组研究
胃肠病学胃肠病学

背景情况:

酸抑制药物 (ASM) 经常在婴儿中使用.
肠道微生物组在早期发育和代谢健康中起着至关重要的作用.
早期药物暴露,肠道殖民化和长期健康结果之间的潜在联系需要调查.

研究的目的:

研究婴儿使用抑制酸性药物 (ASM),特别是质子抑制剂 (PPI) 和组胺-2-受体对抗剂 (H2RAs) 之间的关系.
确定ASM使用与学龄前儿童的体重指数 (BMI) 之间的关联.
检查Clostridioides difficile (C. difficile) 殖民在这种关系中的调解作用.

主要方法:

关于ASM使用的家长报告 (H2RAs,PPI) 从1025名3,6个月和12个月的婴儿收集.
用qPCR对3个月后的便样本进行了评估,以评估Clostridioides difficile的殖民性.
体质指数 (BMI) -z分数计算了5岁儿童的体质指数;进行了回归和调解分析.

主要成果:

婴儿使用H2RA与3个月后C. difficile殖民的可能性增加了两倍 (OR:2.27).
3个月的C. difficile殖民与5年后更高的BMI-z分数 (β:0.31) 有关.
调解分析显示H2RA使用对5年BMI-z分数产生间接的积极影响,由C. difficile殖民 (β:0.065) 调解.

结论:

婴儿接触H2RAs与学龄前BMI增加有关,可能由C. difficile殖民介导.
这些发现突出了肠道微生物组在调解早期药物使用对儿童体重的影响中的作用.
需要进一步的研究来了解ASM使用对婴儿肠道健康和随后代谢结果的长期影响.

关键词:

这是C. difficile.酸性抑制药物药物抑制药物身体质量指数 (BMI) 是指身体质量指数.我们的微生物群.

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