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相关概念视频

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

6.1K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
6.1K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.1K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.1K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

688
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
688
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

5.1K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
5.1K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

4.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
4.3K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

806
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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相关实验视频

Updated: Sep 14, 2025

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

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自抗原选择B细胞:对B细胞选择和功能的新视角

Mike Aoun1, Rikard Holmdahl2,3

  • 1Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

European journal of immunology
|July 23, 2025
PubMed
概括

乙抑制细胞 (Bsup) 通过激活调节性T细胞 (Tregs) 来积极调节免疫平衡. 了解Bsup机制可以通过利用自身活性进行免疫疗法来彻底改变自身免疫性疾病的治疗.

关键词:
B细胞的发育过程这是自身免疫力.免疫调节 免疫调节这是一种炎症炎症炎症炎症.自己/非自己歧视歧视.

更多相关视频

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function
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Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Published on: February 16, 2017

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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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Generation of Human Alloantigen-specific T Cells from Peripheral Blood

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相关实验视频

Last Updated: Sep 14, 2025

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

22.1K
Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function
09:25

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Published on: February 16, 2017

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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
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Generation of Human Alloantigen-specific T Cells from Peripheral Blood

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科学领域:

  • 免疫学 免疫学 免疫学
  • 这是一种自身免疫力.
  • 细胞调节 细胞调节 细胞调节

背景情况:

  • 自我识别塑造了自适应性免疫系统,创造了一个悖论,自主反应对于调节至关重要,但与自身免疫性疾病有关.
  • 骨髓 (BM) 中的B细胞选择传统上被视为负面选择,消除有害的克隆.
  • 新兴证据表明,B抑制细胞 (Bsup) 的一个子集积极调节免疫平衡.

研究的目的:

  • 研究B抑制细胞 (Bsup) 在免疫调节和耐受性中的作用和机制.
  • 探索Bsup如何区分恒常性和致病性自主活性.
  • 通过了解Bsup功能来确定自身免疫性疾病的潜在治疗点.

主要方法:

  • 这项研究重点关注C1特异性Bsup细胞,这些细胞识别了II型原体 (Col2).
  • 研究了Bsup细胞和Col2特异性调节性T细胞 (Tregs) 之间的相互作用.
  • 检查了管理BSup选择,分化和功能的分子机制 (尽管具体方法在摘要中没有详细说明).

主要成果:

  • 特定于C1的Bsup细胞与特定于Col2的Tregs接触,以抑制健康个体的炎症.
  • Bsup细胞似乎在外周和中心耐受性中发挥作用,类似于Tregs.
  • 目前尚不清楚Bsup选择,分化和功能背后的分子机制.

结论:

  • B抑制细胞 (Bsup) 是免疫平衡的关键调节者,与调节性T细胞 (Tregs) 相互作用.
  • 了解Bsup的功能可以将自身免疫性疾病的治疗从消除转变为利用自身反应.
  • 为了准确免疫治疗的发展,需要对Bsup分子机制进行进一步的研究.