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用氧酸盐增强的抗感染CoCrMo-3Cu用于承载性植入物

Amit Bandyopadhyay¹, Cassandra L Orozco¹, Lochan Upadhayay¹

¹W. K. Keck Biomedical Materials Research Lab, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164-2920, United States.

ACS applied materials & interfaces

|July 23, 2025

概括

新的--合金 (CCM) 与铜和酸 (HA) 合金显示出更好的抗菌性和磨损性能. 这些先进的材料为承载性植入物提供了有前途的解决方案,减少了离子的释放,提高了耐用性.

科学领域:

生物材料工程生物材料工程
添加剂制造添加剂制造添加剂制造
部落学 (tribology) 是一个学科.

背景情况:

由于耐磨性,-- (CCM) 合金被用于承载性植入物中.
离子释放和细菌感染是植入物失败的主要原因.
目前的抗生素治疗通常对植入物相关的细菌感染无效.

研究的目的:

开发具有固有的抗菌性质和增强耐磨性的新型CCM合金.
调查铜 (Cu) 和酸 (HA) 添加剂对CCM合金性能的影响.
评估开发的合金的抗菌功效和抗腐蚀行为.

主要方法:

CCM,CCM-3Cu,CCM-3Cu-1HA和CCM-3Cu-2HA合金是使用基于激光的定向能量沉积 (L-DED) 来制造的.
在48小时和72小时内对Pseudomonas aeruginosa进行了抗菌疗效的测试.
在杜尔贝科的改造介质 (DMEM) 中,在5和10N负荷下进行了三角腐蚀研究.

主要成果:

铜的添加增强了CCM合金的抗菌电阻.
添加酸 (HA) 显著改善了耐磨性,CCM-3Cu-2HA比CCM提高了6倍.
添加HA还导致了离子释放的减少.
微观结构分析证实了固体滑性 tribofilm 的形成.

结论:

CCM-3Cu合金表现出固有的细菌耐药性.
用HA增强的CCM-3Cu合金表现出优越的耐磨性和减少的离子释放.
这些HA增强CCM-3Cu合金是承载性植入物接表面的有希望的候选者.

关键词:

这就是 CoCrMoMo 的意思.添加剂制造添加剂制造添加剂制造细菌的耐药性细菌的耐药性氧帕提特是一种氧帕提特.带有 tribofilm 的电影.穿着穿着穿着穿着穿着穿着穿着

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