相关实验视频

Updated: Sep 14, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

在健康和疾病中的NeuN表达:关于神经元异质性的组织学视角

Joongbum Moon^1,2, Ji Hyeon Ahn³, Moo-Ho Won⁴

¹Department of Emergency Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea.

Histology and histopathology

|July 23, 2025

概括

神经元核 (NeuN) 是一个常见的神经元标记物,但它

科学领域:

神经科学是一个神经科学.
神经病理学神经病理学
细胞生物学细胞生物学

背景情况:

神经核 (NeuN) 是用于识别神经科学和神经病理学的成熟神经元的广泛使用的标记物.
在神经元计数,损伤评估和解剖绘图方面,NeuN免疫活性至关重要.
然而,NeuN在所有成熟的神经元中并非普遍表达,其表达在病理条件下可能发生变化.

研究的目的:

审查最近关于NeuN表达模式和调控机制的发现.
讨论NeuN的动态表达对研究和诊断的影响.
提出对NeuN作为神经元状态的动态指标而不是细胞存活的二元标记物的修订理解.

主要方法:

文献综述综合了NeuN表达的最新发现.
对调节NeuN存在或不存在的分子机制的分析.
对神经病理学诊断和神经科学研究的影响的探索.

主要成果:

不是所有成熟的神经元类型 (例如,嗅觉 mitra 细胞,小脑Purkinje 细胞,视网膜光受体) 都表达了 NeuN.
作为对各种病理状况的反应,NeuN表达是动态调节的,例如缺血-再输液损伤,神经退行性疾病和创伤性脑损伤.
NeuN下调可能表明功能性损害或压力,不一定是不可逆转的细胞损失.

结论:

NeuN 消极性不应仅仅被解释为神经元死亡.
NeuN 作为神经元状态的动态指标,受生理和病理因素的影响.
建议使用多标记器策略和先进的分子工具 (例如空间转录组学,RNA测序) 来进行更准确的神经元分析.

更多相关视频

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons

Published on: November 2, 2018

相关概念视频

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Disorders of the Nervous Tissue

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Neurons as Communicators of the Brain

Neurons as Communicators of the Brain

Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...

Excitatory and Inhibitory Effects of Neurotransmitters

Excitatory and Inhibitory Effects of Neurotransmitters

When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...

Neuronal Communication

Neuronal Communication

Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...