齐普罗与普罗波用于胃肠内镜镇静:系统性审查和元分析
Yunfeng Yu1, Juan Deng2, Yuman Yin1
1School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
International journal of surgery (London, England)
|July 23, 2025
概括
齐普罗是一种更安全的替代品,用于胃肠道内静止,显示低血压,呼吸抑制和注射疼痛的降低率. 虽然觉醒时间稍长一点,但它提供了显著的安全益处.
科学领域:
- 麻醉学 麻醉学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 醇是一种醇衍生物,在中国越来越多地用于镇静.
- 在胃肠道内镜镇静中,西普罗的疗效和安全性需要进一步评估.
- 这一元分析比较了用于胃肠内镜的西普罗和普罗波.
研究的目的:
- 为了比较西普罗福尔与普罗波福尔在胃肠道内镜镇静中的疗效和安全性.
- 评估与西普罗和普罗波相关的不良事件的发生率.
- 确定西普罗是否是内镜手术中可行的替代品.
主要方法:
- 在四个公共数据库中搜索到2025年2月1日之前的相关文献.
- 包括9项研究,1860名参与者,不包括基于预定义标准的研究.
- 进行元分析和试验顺序分析 (TSA) 来评估结果.
主要成果:
- 与普罗波相比,西普罗显著降低了低血压,呼吸抑制,低氧化,窒息咳和注射疼痛的发生率.
- 使用西普罗福尔,觉醒时间略有延长,但在临床上没有显著意义.
- TSA证实了低血压,低氧化,呼吸抑制和注射疼痛的结果的决定性;没有检测到出版偏差.
结论:
- 齐普罗在胃肠内镜镇静中比普罗波具有优势,不良事件的发生率较低.
- 剂量为0.4mg/kg的西普罗是一种有效的替代品,可以减少非自愿的运动.
- 建议在较长的手术 (≥10分钟) 期间使用西普罗时对潜在的头保持谨慎.
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