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Updated: Sep 14, 2025

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伪uridimycin的结构-活动关系 专注于提高化学稳定性

Ryotaro Okawa1, Irina Artsimovitch2, Akira Katsuyama1,3

  • 1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

Journal of medicinal chemistry
|July 23, 2025
PubMed
概括

针对细菌RNA聚合酶的抗生素pseudouridimycin (PUM) 的新类型被设计为提高化学稳定性和结合亲和力. 这些研究解决了对抗药物耐药细菌的新型抗菌剂的关键需求.

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