对已证实或推定感染病因的淋巴瘤季节性发生的观察
Ioannis Anagnostopoulos1,2, Viktoria Buck1,2, Elena Gerhard-Hartmann1,2
1Institute of Pathology, University of Würzburg, Würzburg, Germany.
Frontiers in oncology
|July 23, 2025
概括
经典霍奇金淋巴瘤 (CHL) 呈现季节性发生模式,在春季初达到峰值,并在夏末下降. 具有感染联系的淋巴瘤和COVID-19期间没有表现出显著的季节性聚类.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 有限的研究存在于淋巴瘤季节性,之前的研究产生了相互矛盾的结果.
- 假设表明,在特定的患者群体中,季节性淋巴瘤发生的潜在感染病因.
研究的目的:
- 调查各种淋巴瘤实体的季节性发生模式.
- 为了确定具有感染联系的淋巴瘤是否表现出季节性聚类.
- 评估COVID-19流行病对观察到的季节性模式的影响.
主要方法:
- 来自德国参考中心的8038例淋巴瘤病例的分析.
- 包括经典的霍奇金淋巴瘤 (CHL),EBV阳性CHL,结节性淋巴细胞占主导地位的HL,皮肤/肺边缘区域淋巴瘤 (MZL),毛细胞白血病 (HCL) 和扩散大的B细胞淋巴瘤 (DLBCL).
- 在COVID-19大流行之前和期间 (2020-21) 检查季节性模式.
主要成果:
- 经典霍奇金淋巴瘤 (CHL) 呈现季节性波动,在第一季度达到峰值,在第三季度达到低谷.
- 在结节性硬化性CHL和年轻患者 (0-39岁) 中也发现了类似的模式.
- 在EBV阳性CHL,MZL或HCL中没有发现季节性模式;COVID-19大流行并没有显著改变CHL季节性.
结论:
- 经典霍奇金淋巴瘤 (CHL) 呈现出明显的季节性发生,与具有传染性关联的淋巴瘤不同.
- 传染病因似乎没有驱动MZL或HCL的季节性聚类.
- COVID-19大流行并没有破坏CHL的既定季节性模式.
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