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Updated: Sep 14, 2025

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
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Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

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工程化乙化胰岛素纳米颗粒用于增强口服胰岛素输送:持续释放,结构稳定性和体内有效性

Achmad Ramadhanna'il Rasjava1,2, Neng Fisheri Kurniati3, Rukman Hertadi1

  • 1Biochemistry and Biomolecular Engineering Research Division, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology Bandung West Java Indonesia rhertadi@itb.ac.id.

RSC advances
|July 23, 2025
PubMed
概括

这项研究开发了乙化胰岛素纳米颗粒,以保护口服胰岛素免受降解,显著提高了其生物可用性和降低小鼠血糖水平的有效性.

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
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α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
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