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相关概念视频

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

125
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
125
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

220
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
220
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

987
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
987
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

149
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
149
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

210
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
210
Schizophrenia01:17

Schizophrenia

228
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
228

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相关实验视频

Updated: Sep 14, 2025

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
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在精神分裂症中,努力分配受损.

Elodie Blouzard1, Fabien Cignetti1, Florent Meyniel2,3

  • 1Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences, 38000 Grenoble, France.

Schizophrenia research. Cognition
|July 23, 2025
PubMed
概括

精神分裂症患者表现出受损的动态成本/收益决策. 这影响了努力分配,导致收益减少,并有助于精神分裂症的动机.

关键词:
动机 激励 激励决策方式 决策方式动态的努力分配分配.负面的症状是负面的症状.精神分裂症是一种精神分裂症.

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科学领域:

  • 认知神经科学 认知神经科学
  • 精神病学是一个精神病学.
  • 决策科学 决策科学 决策科学

背景情况:

  • 努力分配对于理解精神分裂症的动机至关重要.
  • 精神分裂症可能涉及动态成本/收益决策过程中的缺陷.

研究的目的:

  • 调查精神分裂症是否与动态成本/收益决策中的障碍有关.
  • 检查任务难度和激励水平如何影响精神分裂症患者的努力分配,与健康对照人群相比.

主要方法:

  • 使用了修改后的努力分配任务.
  • 参与者在30秒间隔内分配了努力,以最大限度地提高收益.
  • 难度和激励对努力分配的影响被逐个试验分析.

主要成果:

  • 精神分裂症患者 (N=25) 与对照组 (N=25) 相比,他们对任务参数的动态适应能力降低.
  • 患者对难度和激励水平的适应能力下降.
  • 精神分裂症患者花费的时间较少,导致整体收益较低.

结论:

  • 精神分裂症患者在努力成本决策方面有选择性障碍.
  • 这些缺陷可能是精神分裂症患者低于最佳的努力分配和目标导向活动减少的基础.