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独立的风险和保护因子对氧沙胺诱导过敏反应:一个回顾性研究
Jing Xue1,2,3, Zhihao Lian4, Xiaoyan Li1,2,3
1Department of Pharmacy, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Frontiers in pharmacology
|July 23, 2025
概括
在结直肠癌 (CRC) 患者中,牛氧 (OXA) 的过敏反应 (HSR) 与治疗中断,先前的过敏和异常的中性粒细胞有关. 预防性预治疗显著降低了HSR风险.
科学领域:
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 氧沙 (OXA) 是结直肠癌 (CRC) 和胃癌的关键化疗剂.
- 奥克沙利普拉丁诱导的过敏反应 (HSR) 是一个重大的临床挑战,可能导致危及生命的事件.
- 识别OXA-HSRs的风险和保护因素对于CRC治疗中的患者安全至关重要.
研究的目的:
- 调查与中国结直肠癌 (CRC) 患者因牛氧产生的过敏反应 (HSR) 相关的独立风险和保护因素.
- 提供以证据为基础的建议,以减轻在接受牛利治疗的CRC患者的HSR.
主要方法:
- 在2022年6月至2022年12月期间,对233名中国结直肠癌 (CRC) 患者进行了回顾性分析,这些患者接受了oxaliplatin (OXA) 治疗.
- 从医院记录中提取人口统计数据和病史.
- 单变量和多变量逻辑回归分析以确定OXA-HSRs的独立风险和保护因素.
主要成果:
- 在233名患者中,有51名患者 (21.9%) 患有OXA-HSR,中位数在第4个治疗周期发病.
- 高血压反应的独立风险因素包括:长时间的OXA中断 (≥30天),以为基础的药物过敏史和异常绝对中性粒细胞数.
- 使用双药或三药预防方案的预治疗是对HSRs的独立保护因素 (OR = 0.37,95% CI = 0.17-0.82).
结论:
- 长期暂停oxaliplatin治疗,先前的白金过敏史和异常的中性粒细胞计数是hsr的重要危险因素.
- 预防性预治疗方案 (双/三重药物) 显示出对OXA诱导的HSRs的保护作用.
- 临床医生应评估这些风险因素,并考虑加强预治疗策略,以尽量减少CRC患者的HSR发病率.
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