抑郁情绪会影响生物衰老的过程,来自NHANES数据集的分析
Yuan Tian1,2, Qiao Lu1,2, Jing Li1,2
1Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Frontiers in aging
|July 23, 2025
概括
抑郁症状与加速的生物衰老有关,也被称为三角洲年龄. 改善情绪可能有助于减缓这个衰老过程.
科学领域:
- 老年学是一门学科.
- 精神病学是一个精神病学.
- 生物标志物 生物标志物
背景情况:
- 抑郁情绪可能会影响生物衰老过程.
- 生物年龄和时间年龄 (delta年龄) 之间的差异是一个关键的指标.
- 这项研究调查了抑郁情绪和全身三角洲年龄之间的联系.
研究的目的:
- 探索抑郁情绪与生物衰老之间的关联.
- 为了确定抑郁症症状是否加速生物衰老.
- 为了确定缓解加速衰老的潜在干预措施.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2007-2018) 中对7,383名美国成年人的分析.
- 使用患者健康问卷-9 (PHQ-9) 评分评估抑郁情绪.
- 从循环生物标志物估计生物年龄 (BA) 并计算三角年龄 (δ-age).
主要成果:
- 后勤回归显示,抑郁症状升高与生物衰老加速之间存在显著的关联.
- 限制立方线 (RCS) 显示,抑郁症得分和生物衰老风险之间存在积极的剂量反应关系.
- 权重定量总回归 (WQS) 显示出积极的趋势,过度进食和低自我认知显著影响PHQ-9分数.
结论:
- 抑郁症状与加速的生物衰老有着显著的联系.
- 针对情绪改善的干预措施可能会减缓生物衰老.
- 这项研究表明,通过情绪管理来延缓整体衰老过程的途径.
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