益生菌作为代谢功能障碍相关的脂肪性肝病的治疗策略:系统性审查和元分析
Jing Lu1, Xiaoxiao Dong1, Ziqi Gao1
1College of Smart Agriculture (Research Institute), Xinjiang University, Urumqi, 830046, China.
Current research in food science
|July 23, 2025
概括
益生菌显著改善了与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的肝功能和脂质概况. 这一元分析证实了它们在MASLD管理中的治疗潜力.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个普遍存在的全球健康问题.
- 通过益生菌调节肠道微生物群是MASLD的潜在治疗途径.
研究的目的:
- 系统地审查和分析益生菌补充对MASLD患者的影响.
- 量化益生菌对肝功能,脂质代谢和MASLD炎症标志物的影响.
主要方法:
- 12项随机对照试验的系统综述和元分析.
- 包括657名参与者与MASLD.
- 对肝酶,脂质样本和炎症标志物的分析.
主要成果:
- 益生菌显著降低了肝酶 (ALT,AST,GGT) 和脂质标记物 (TG,TC,LDL-C).
- 益生菌显著增加了HDL-C水平.
- 亚组分析表明成年人更明显的益处,在儿科患者群体中一致性更高.
结论:
- 益生菌补充剂在改善MASLD患者的肝功能和脂质代谢方面具有显著的潜力.
- 研究结果支持益生菌作为MASLD的有价值干预措施,并考虑与年龄相关的疗效.
- 这一元分析为开发针对MASLD的向益生菌干预提供了基础.
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