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Updated: Sep 14, 2025

Single Particle Cryo-Electron Microscopy: From Sample to Structure
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Single Particle Cryo-Electron Microscopy: From Sample to Structure

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隐藏空间扩散模型的端到端训练,用于冷-电磁重建中的形状异质性

Zixi Hu1, Kanupriya Pande2

  • 1Department of Mathematics, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

International Conference Image and Vision Computing New Zealand : [proceedings]. International Conference Image and Vision Computing New Zealand
|July 23, 2025
PubMed
概括

本研究引入了一种新的端到端方法,用于联合训练变化自编码器 (VAE) 和扩散模型,改进生物分子构造景观的建模,并使可信的过渡路径产生.

关键词:
低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.扩散模型的扩散模型动力学 动力学 动力学生成式建模生成式建模不同质性的异质性

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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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