中年和老年人血清总白血素与虚弱之间的关系
Cunbao Ling1,2, Libing Tian2, Chunyan Zhang1,3
1Department of Medical Innovation Research, Chinese PLA General Hospital, Beijing, China.
Frontiers in medicine
|July 23, 2025
概括
较高的血清总 bilirubin (STB) 水平与45-85岁的成年人脆弱的风险较低有关. 这表明白素可能在这个年龄组中起到保护性作用,防止脆弱.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 生物化学 生物化学
背景情况:
- 脆弱性是一个日益严重的公共卫生问题,特别是在老年人中.
- Bilirubin 的健康益处是公认的,但它与脆弱的关联需要进一步的研究.
研究的目的:
- 探索45-85岁成年人血清总 bilirubin (STB) 水平和虚弱之间的关系.
- 为了确定STB水平是否与脆弱风险独立相关.
主要方法:
- 利用了2015-2020年国家健康和营养检查调查 (NHANES) 8,603名参与者的数据 (年龄为45-85岁).
- 使用49-赤字指数评估脆弱性,并通过Jendrassik-Grof方法测量STB.
- 员工调查加权后勤回归和受限立方支线 (RCS) 分析.
主要成果:
- 较高的STB水平与脆弱性风险降低有关 (在完全调整的模型中,每单位增加减少5%).
- 在STB的第二个和第三个三位数中,个体的脆弱率显著降低 (ORs为0.75和0.59).
- RCS分析显示了显著的非线性,L形关联 (P=0.0075),其保护作用低于17.1μmol/L.
结论:
- 在生理范围内的血清总 bilirubin 度升高与中老年人和老年人的脆弱性有负面关联.
- 较高的胆红素水平可能会对脆弱的发展产生保护作用.
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