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在笔光束扫描格兰特上为Uveal黑色素瘤进行质子疗法

Hang Qi¹, Lei Hu^1,2, Sheng Huang^1,3

¹New York Proton Center, New York, New York, USA.

Advances in radiation oncology

|July 23, 2025

概括

对眼睛瘤的质子疗法可以在没有专门的孔隙的情况下有效地进行,从而扩大了全球的访问. 特定于光束的孔径进一步降低了周围器官的辐射剂量,同时保持了治疗的有效性.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
眼科医生眼科眼科

背景情况:

质子疗法为眼部瘤提供精确的辐射输送.
标准笔光束扫描 (PBS) 门廊房可能缺乏专门的开口,可能会限制访问.
光束特定开口 (BSAs) 在眼睛质子疗法中探索剂量学益处.

研究的目的:

为了评估治疗眼睛瘤的可行性和结果,使用没有孔径的标准PBS门架室.
研究在眼睛质子疗法中结合光束特定开口 (BSA) 的剂量测量优势.
评估扩大全球对眼睛癌症质子疗法的获取潜力.

主要方法:

对11名用PBS质子疗法治疗的乳膜黑色素瘤患者的回顾性分析.
使用合成CT和蒙特卡洛模拟,比较计划剂量与输送剂量.
评估目标覆盖率 (D95%) 和风险器官剂量,包括BSA和没有BSA.

主要成果:

计划和输送剂量之间的密切一致 (D95%偏差在3.6%内).
使用和不使用BSA实现了类似的目标覆盖率 (101% ± 1.0% vs. 101% ± 3.2%).
BSAs显著降低了对邻近器官 (例如视网膜,角膜,透镜) 的平均和最大剂量,在非突出器官中显著减少.

结论:

成功实施眼性质子疗法,使用标准的PBS梁线,没有孔径.
特定于光束的开口可以提高对周围器官的剂量降低,同时保持目标覆盖率.
这种方法可以在全球范围内显著扩大对拯救视力的眼性质子疗法的使用.

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