通过缩小精子成熟机制的知识差距来改善辅助生殖的精子选择策略
Hanah May Hart1,2, Brett Nixon1,2, Jacinta Hope Martin1,2
1Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia.
Human reproduction open
|July 23, 2025
概括
在辅助生殖技术 (ART) 中改善精子选择是至关重要的. 通过模仿自然选择,特别是精子 - 带光体结合,我们可以增强ART的成功并减少对后代的风险.
科学领域:
- 生殖生物学和医学生殖生物学和医学
- 遗传学和表观遗传学
- 辅助生殖技术 (ART) 是一种辅助生殖技术.
背景情况:
- 男性因素约占全球不孕症病例的50%,导致ART的使用增加.
- 目前的ART方法绕过了自然精子选择,冒着受精的风险与受损的雌同体和潜在的不良后代结果.
- 需要先进的精子选择工具来模拟自然障碍,以确保ART中的最佳性质.
研究的目的:
- 弥合精子成熟生物学和临床精子选择策略之间的差距,以改善ART结果.
- 审查当前临床精子选择技术,评估其生理相关性和局限性.
- 利用对精子成熟和 zona pellucida (ZP) 的知识开发下一代精子选择方法.
主要方法:
- 在PubMed数据库中进行了全面的文献搜索,使用与精子选择,ART,男性不孕症和相关生物过程相关的关键词进行了搜索.
- 该搜索涵盖了1972年至2024年期间以英语出版的同行评审文章.
- 还检查了选定的文章中的引用,以确保进行彻底的审查.
主要成果:
- 自然受精包括选择高质量的精子,确保健康的受精和胚胎发育.
- ART的高干预技术绕过了自然选择,可能导致遗传缺陷的传播并影响后代的健康.
- 目前的ART精子选择方法在活产率上提供了有限的改善;精子-ZP结合提供了一个有希望的,但尚未充分利用的选择途径.
结论:
- 了解自然性质子选择的差距仍然存在,这给当前的ART实践带来了风险,并对未来几代人造成了潜在的健康后果.
- 将精子成熟的知识与新型人工选择方法相结合,可以显著改善临床ART结果.
- 开发新的精子选择策略,以自然过程为灵感,例如ZP结合,对于推进生殖医学至关重要.
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