沙法兰提取物对中度失眠的成年人睡眠质量的影响:一个分散的,随机的,双盲的,安慰剂控制的试验
Julius Schuster1, Christin Mundhenke1, Hannah Nordsieck1
1Leibniz University Hannover, Institute of Food and One Health, Germany.
Sleep medicine: X
|July 23, 2025
概括
沙夫兰提取物在四周后显著减少了成年人中适度失眠的失眠和感知压力. 这种自然干预也改善了睡眠质量和一些心理症状.
科学领域:
- 营养神经科学 营养神经科学
- 心理药理学 心理药理学
背景情况:
- 睡眠障碍和压力是影响整体幸福感的普遍问题.
- 自然干预措施,如番茄提取物,越来越多地被探索其治疗潜力.
- 番石榴 (Crocus sativus L.) 含有生物活性化合物,具有抗焦虑和调节睡眠的特性.
研究的目的:
- 为了评估标准化沙夫兰提取物 (Safr'InsideTM) 在改善中度失眠的成年人睡眠和心理结果方面的有效性.
- 为了比较两种不同剂量的石榴提取物 (20毫克和30毫克) 与安慰剂的影响.
主要方法:
- 一个3臂,随机,双盲,安慰剂对照试验进行了4周.
- 165名中度失眠的成年人被随机分配,每天接受30毫克沙夫兰提取物,20毫克沙夫兰提取物或安慰剂.
- 主要终点:失眠症状的变化 (雅典失眠量表,AIS). 二级终点包括睡眠质量,感知压力,心理困扰和生活质量.
主要成果:
- 与安慰剂相比,沙夫兰提取物 (20毫克和30毫克) 显著减少了失眠症状 (AIS).
- 这两种沙夫兰提取物剂量都导致了睡眠质量 (SQS) 和感知压力 (PSS) 的显著改善.
- 30毫克的剂量显示出改善心理症状的趋势 (PHQ-4),而其他次要结果没有显示出显著差异.
结论:
- 每天服用沙夫兰提取物 (20毫克或30毫克) 四周有效降低中度失眠的成年人失眠和感知压力.
- 番石榴提取物显示出作为睡眠障碍和相关心理困扰的自然干预的潜力.
- 需要进一步的研究来探索长期影响,并确定可能受益最多的特定患者子组.
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