评估短期的角膜内皮变化后内注射抗VEGF注射在治疗先的眼睛
Anandsagar Kanna1, Avadhesh Oli1, Santosh Kumar1
1Department of Ophthalmology, Command Hospital Airforce, Bangalore, Karnataka, India.
Romanian journal of ophthalmology
|July 23, 2025
概括
静脉内抗VEGF注射可能会导致角膜内皮细胞的暂时变化,特别是细胞变异的增加. 对于视网膜疾病患者来说,内皮细胞形态的这些微妙的短期变化通常没有临床意义.
科学领域:
- 眼科医生 眼科 眼科
- 角质科学 角质科学
- 视网膜疾病 视网膜疾病
背景情况:
- 角膜的透明度依赖于一个健康的内皮.
- 内皮细胞损失可能会损害透明度.
- 内抗VEGF注射用于视网膜疾病.
研究的目的:
- 评估内抗VEGF注射对角膜内皮的短期影响.
- 为了评估注射后内皮细胞形态的变化.
主要方法:
- 对47名以前未接受过治疗的患者进行前性队列研究.
- 用于分析的非接触型光学显微镜.
- 角膜内皮参数 (ECD,细胞数,CV,六角性) 在注射前和后在不同时间点测量.
主要成果:
- 在注射后1周和1个月观察到内皮细胞变异 (多重性) 的过渡性增加.
- 没有检测到内皮细胞数量,密度或六角性的显著变化.
- 在发光/伪发光眼或抗VEGF药物之间没有发现差异.
结论:
- 静脉内抗VEGF注射可以诱导角膜内皮细胞的微妙,短暂的形态变化.
- 这些变化,主要是细胞变异的增加,通常会消失,并且在临床上并不令人担忧.
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