晚期肺癌炎症指数与美国慢性阻塞性肺病成年人死亡率之间的关联
Xiaozhou Su1, Huiqing Rao2, Chunli Zhao1
1Department of Cardiology, Minzu Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
概括
晚期肺癌炎症指数 (ALI) 可以预测慢性阻塞性肺病 (COPD) 患者的死亡率. 较高的ALI得分与减少所有原因死亡风险,心血管疾病和慢性下呼吸道疾病有关.
科学领域:
- 肺部医学 肺部医学
- 生物标志物 生物标志物
- 流行病学 流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 管理需要可靠的预后标志物.
- 晚期肺癌炎症指数 (ALI) 是一个新的标志物,反映了炎症和营养状况.
研究的目的:
- 评估晚期肺癌炎症指数 (ALI) 与COPD患者全因和因特定死亡率之间的关联.
主要方法:
- 分析了4616名患有COPD的成年人的数据 (1999-2018年NHANES).
- 利用多变量Cox比例危险模型和受限立方线来评估lnALI和死亡率之间的关联.
- 采用时间依赖的ROC曲线用于预测性绩效评估和对eGFR作用的调解分析.
主要成果:
- 较高的lnALI显着与所有原因,心血管和CLRD死亡率的风险降低有关.
- 对所有原因和心血管死亡率观察到的L形关联.
- eGFR部分调解了lnALI和死亡结果之间的关联.
结论:
- 在COPD患者中,较高的lnALI值与较低的死亡风险显著相关.
- 晚期肺癌炎症指数 (ALI) 显示了COPD死亡率的预测价值.
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