COVID-19对慢性阻塞性肺病的长期影响
Chi-Tai Lee1, Ping-Huai Wang1,2,3, Shih-Lung Cheng1,4
1Division of Pulmonology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
概括
患有2019年冠状病毒病 (COVID-19) 感染慢性阻塞性肺病 (COPD) 的患者面临更高的死亡率和更频繁的严重恶化. 这些风险无论住院或门诊状态如何,都会持续存在,这凸显了需要谨慎管理的必要性.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 慢性阻塞性肺病 (COPD) 是2019年冠状病毒病 (COVID-19) 患者已知的负预后因素.
- 由于研究有限,COPD患者的COVID-19的长期并发症尚未得到充分了解.
研究的目的:
- 研究COPD患者COVID-19的临床结果和长期并发症.
- 为了比较COPD患者与COVID-19患者之间的特征,恶化和生存率.
主要方法:
- 从2020年1月到2022年12月,对696名COPD患者进行了回顾性研究.
- 分类为COVID-19 (n=86) 和非COVID-19 (n=610) 组.
- 对人口统计,临床特征,COPD急性恶化 (AECOPD) 和生存率的比较分析,对住院患者和门诊患者的COVID-19病例进行亚组分析.
主要成果:
- COVID-19组年龄较大 (75.0与72.0岁),死亡率较高 (4.6%与0%) 和AECOPD频率较高 (0.17与0.08每年).
- COVID-19感染是AECOPD发病率增加的一个独立风险因素 (aOR: 1.74;95%CI: 1.07-2.83).
- 在COVID-19组中,住院患者心力衰竭率较高 (20%对2.8%),强迫活力能力较低,与门诊患者相比.
结论:
- 年龄是COPD患者COVID-19的重要危险因素.
- 在COPD患者中,COVID-19感染增加了严重恶化和死亡风险的频率.
- 在COVID-19后,对严重恶化的敏感性增加是独立于护理环境 (住院/门诊).
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