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与白血病和淋巴瘤死亡率相关的因素与COVID-19:全国住院患者样本分析 (2020-2021)
Saketh Palasamudram Shekar1, Barath Prashanth Sivasubramanian2, Diviya Bharathi Ravikumar3
1Interventional Pulmonology, Pulmonary and Sleep Associates of Huntsville, Huntsville, USA.
Cureus
|July 23, 2025
概括
在美国,COVID-19显著增加了白血病和淋巴瘤患者的死亡率. 2020-2021年死亡率急剧上升,凸显了需要改进癌症患者护理策略的需要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 患有血液性恶性瘤的患者有较高的COVID-19死亡风险.
- 了解COVID-19对白血病和淋巴瘤患者的影响对于管理免疫受损个体至关重要.
- 在疫情期间,这些患者群体的死亡率模式存在有限的研究.
研究的目的:
- 为了确定美国白血病和淋巴瘤患者的COVID-19死亡风险.
- 从2020年到2021年分析这些队列中的COVID-19死亡率趋势.
主要方法:
- 分析国家住院样本数据库 (2020-2021) 针对COVID-19成人白血病和淋巴瘤患者的分析.
- 使用描述性分析,倾向匹配和多变量回归.
- 对四分位数的死亡风险进行比较,并确定四分位数的趋势.
主要成果:
- 白血病患者的死亡率为14.7%;淋巴瘤患者的死亡率为19.7%.
- 多变量回归显示,COVID-19的白血病和淋巴瘤患者的死亡率增加了两倍.
- 器官和骨髓功能障碍显著增加了死亡率;死亡率激增在2020年底和2021年达到顶峰.
结论:
- COVID-19与白血病和淋巴瘤患者的死亡率显著增加有关.
- 从2020年10月到2021年3月,确定的死亡率急剧上升,这对于预测癌症患者未来风险至关重要.
- 临床医生必须对患有COVID-19和并发性疾病的血液性恶性瘤患者进行治疗和提前临床试验.
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