周围动脉疾病 在西非糖尿病患者中:风险因素分析分析
Joachim Amoako1, Matthan Fayia Saa2,3, Emmanuel Bannerman-Williams1,4,5
1Department of Surgery, University of Ghana Medical School, Ghana.
概括
患有糖尿病的西非成年人患外周动脉疾病 (PAD) 的风险随着更容易修改的风险因素显著增加. 管理高血压,病,肥胖和高的LDL胆固醇对于预防PAD至关重要.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 血管医学 血管医学
背景情况:
- 周围动脉疾病 (PAD) 影响全球超过2亿人,糖尿病患者的患病率更高.
- 关于糖尿病PAD风险因素的先前研究在很大程度上排除了西非人群,他们可能具有不同的血管生物学.
- 这项研究的重点是描述可修改的风险因素对PAD的影响,特别是在西非成年糖尿病患者中.
研究的目的:
- 为了调查加纳成年糖尿病患者中PAD的患病率.
- 在这个人群中确定与PAD相关的可修改的风险因素.
- 为了确定这些风险因素对PAD几率的累积影响.
主要方法:
- 进行了一项横截面研究,涉及803名被诊断患有糖尿病的加纳成年人.
- 使用脚-手臂压力指数 (ABI ≤0.90) 和/或间歇性的存在来确定PAD.
- 使用多变量逻辑回归模型确定独立的风险因素,并评估它们对PAD患病率的综合影响.
主要成果:
- 研究人口的平均年龄为59.8岁,糖尿病持续时间为13.7年,平均HbA1c为8.45%.
- 发现PAD的患病率为25.8%.
- PAD的独立风险因素包括高血压 (OR 2.00),慢性病 (OR 1.54),中心肥胖 (OR 1.58) 和升高的LDL胆固醇 (OR 1.42). 随着存在的风险因素数量的增加,PAD的几率大幅增加,在具有四个风险因素的人群中达到近五倍.
结论:
- 患有糖尿病的西非成年人对高血压,慢性病,中心肥胖和高LDL胆固醇的联合影响对PAD发展表现出高度敏感.
- 这些发现强调了解决这些可修改的风险因素的重要性,以指导PAD查和治疗策略.
- 这项研究强调了需要文化特定的方法来管理糖尿病人群的血管健康.
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